What diseases do you think Amgen should focus on when trying to develop the next blockbuster drugs? Let us know, and look for follow-up responses from C-Suite editor Geoff Colvin.

We’re just six months in, but what do you think the dumbest moment of the year is?

In a Fortune investigation — How Bernie Did It, by James Bandler and Nicholas Varchaver — secrets of Madoff’s massive swindle are uncovered. What do you think of the Madoff mess?

Allan Sloan invites you to post your questions to him about Wall Street, dealmaking and the state of the financial crisis. He’ll choose several questions to answer in a future online installment of his column, The Deal.

In “The secret history of Bear Stearns’ collapse,” William Cohan looks back to the roots of the misadventure in which Bear Stearns traders Ralph Cioffi and Matthew Tannin lost roughly $1.6 billion while allegedly misleading investors, and illustrates how the missteps of the few can have consequences for the many.

Who do you think is most at fault in Bear Stearns’ collapse?

In “The New Jobless,” Jennifer Reingold tells the stories of 12 people who never thought they’d have trouble finding a good job, but found this recession trumped their hard-won credentials and experience.

Has the recession had an impact on your career? How are you coping with the downturn? Tell us your story.

Conover thinks Abbott is getting Advanced Medical at a good price.  But Dodds thinks the company could have spent the money in a better way. What do you think?

In “Origins of the bear market” in the January 19 issue of Fortune, David Whitford explores the etymology of the terms bull and bear market. Turns out there are many theories – bears hibernate while bulls fight, bears tear their food down with their claws while bulls throw things up with their horns, and one theory involving London bearskin wholesalers being overly optimistic. What’s your explanation? Share it here.

Do you think Social Security is a Ponzi scheme?

In “Three days that shook the world“ William Cohan takes an in-depth look at the frantic 72 hours before Lehman declared bankruptcy, exactly three months ago. Now that we can look back at what happened after Lehman collapsed, what do you think: Did the government do the right thing when it let Lehman fail?